Wednesday, November 2, 2016

breast cancer

Breast Carcinoma Treated by a Regimen of Low-Dose Chemotherapy and insulin: Report of Four Cases and Pharmacokinetic Considerations.
SGA, Donato Perez Garcia y Bellon, and Donato Perez Garcia, Jr.
Poster abstract for Forty-second Annual Symposium on Fundamental Cancer Research
Cellular and Molecular Targets of Cancer Therapy, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas, October 24-27, 1989.
Published on IPTQ with permission of Donato Perez Garcia, M.D.
We report four cases of breast carcinoma (infiltrating ductal type, stages II to IV) treated abroad with an innovative approach using insulin as a pharmacologic adjunct to a protocol of low-dose combination cyclophosphamide, methotrexate, and 5-fluorouracil (CMF). On a weekly basis, patients received 5 days of oral and 2 days (Monday, Thursday) of parenteral chemotherapy, the latter administered together with 0.1 to 0.2 units/kg of regular insulin (mean treatment, 8 weeks).
Significant improvements were seen in the clinical course of each patient through reduction in size or disappearance of the primary, regression of metastases, changes in laboratory and radiologic parameters, and improvements in Karnofsky scores. The regimen. was tolerated by all four patients, without dose-related side effects.

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